Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

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Maternal high-fat diet effects on third-generation female body size via the paternal lineage.

The health consequences of in utero exposure to maternal obesity on future generations are concerning because they contribute to increased rates of diabetes, cardiovascular disease, and metabolic syndrome. We previously reported that maternal high-fat diet exposure in mice resulted in an increase in body size and reduced insulin sensitivity that persisted across two generations via both materna...

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C57BL/6J (B6) mice are susceptible to high-fat diet (HFD)-induced obesity and have been used in metabolism research for many decades. However, the genetic component of HFD-induced obesity has not yet been elucidated. This study reports evidence for a paternal transmission of HFD-induced obesity and a correlated expression of Igf2 and Peg3 (paternal expressed gene 3) imprinted genes. We found th...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 2011

ISSN: 0013-7227,1945-7170

DOI: 10.1210/en.2010-1461